![]() Also, we highlight the possibility of utilizing heterochromatin protein 1 as a prognostic marker and a therapeutic target of cancer.ĭysregulation of epigenetic mechanisms as well as genomic mutations contribute to the initiation and progression of cancer. In the present review, we summarize the studies conducted on the relationship between heterochromatin protein 1 and cancer. ![]() Despite the studies suggesting its role in tumorigenesis, the precise tumorigenic mechanism of heterochromatin protein 1 in each cancer type is still not established. The changed expression pattern of heterochromatin protein 1 is associated with tumorigenesis as it regulates diverse mechanisms such as heterochromatin formation, transcriptional regulation, DNA repair, cell cycle, and telomere maintenance. Indeed, numerous studies report on the altered expression level of heterochromatin protein 1 in various cancers. Since its discovery, the crucial roles of heterochromatin protein 1 in tumorigenesis have been constantly reported. It acts as a transcriptional corepressor by forming heterochromatin. ![]() Heterochromatin protein 1 is a histone code reader protein that recognizes histone H3 lysine 9 methylation.
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